The Evaluation of an Effective Dosage of Caronamide

It has been shown by Beyer et al. in a recent series of papers ( 1 to 4) that the compound 4-carboxyphenylmethanesulfonanilide, known as Caronamide, is effective in increasing the penicillin plasma concentration and in prolonging the period of time over which detectable penicillin plasma concentrations are maintained following administration of penicillin, orally and by venoclysis, to dogs. In these experiments it was demonstrated that the renal tubular excretion of penicillin could be completely suppressed (2) when the antibiotic was given concomitantly with adequate amounts of Caronamide. In a series of experiments in children (5), Caronamide used in conjunction with penicillin administered orally was effective in increasing the penicillin plasma concentration from 2.8to 14.5fold over the penicillin controls and was also found to be of a low order of toxicity at the dosages employed. The purpose of the present research was to determine an optimum dose of Caronamide for children.